MSCs rescue impaired wound healing in a murine LAD1 model by adaptive responses to low TGF‐β1 levels

Mutations in the CD18 gene encoding the common β‐chain of β2 integrins result in impaired wound healing in humans and mice suffering from leukocyte adhesion deficiency syndrome type 1 (LAD1). Transplantation of adipose tissue‐derived mesenchymal stem cells (MSCs) restores normal healing of CD18(−/−)...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EMBO Rep
Prif Awduron: Jiang, Dongsheng, Singh, Karmveer, Muschhammer, Jana, Schatz, Susanne, Sindrilaru, Anca, Makrantonaki, Evgenia, Qi, Yu, Wlaschek, Meinhard, Scharffetter‐Kochanek, Karin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2020
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132342/
https://ncbi.nlm.nih.gov/pubmed/32080965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949115
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