Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1.

The human immunodeficiency virus (HIV) genome codes for a trans-activating regulatory protein, tat. Using chemically synthesized tat, it was found that 125I-tat and 125I-tat38-86 specifically bound to rat brain synaptosomal membranes with moderate affinity (K0.5 = 3 microM). Interaction of tat with...

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Autori principali: Sabatier, J M, Vives, E, Mabrouk, K, Benjouad, A, Rochat, H, Duval, A, Hue, B, Bahraoui, E
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1991
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC239839/
https://ncbi.nlm.nih.gov/pubmed/1898974
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