Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1.

The human immunodeficiency virus (HIV) genome codes for a trans-activating regulatory protein, tat. Using chemically synthesized tat, it was found that 125I-tat and 125I-tat38-86 specifically bound to rat brain synaptosomal membranes with moderate affinity (K0.5 = 3 microM). Interaction of tat with...

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Publicado en:J Virol
Main Authors: Sabatier, J M, Vives, E, Mabrouk, K, Benjouad, A, Rochat, H, Duval, A, Hue, B, Bahraoui, E
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239839/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1898974/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.2.961-967.1991
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