Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.

The herpes simplex virus type 1 (HSV-1) ICP4 protein is a transcriptional activator of many eucaryotic RNA polymerase II promoters. The HSV-1 thymidine kinase gene (tk) promoter is induced by ICP4 and contains binding sites for the cellular transcription factors TFIID, Sp1, and CCAAT-binding protein...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Imbalzano, A N, Coen, D M, DeLuca, N A
Format: Artigo
Langue:Inglês
Publié: 1991
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC239793/
https://ncbi.nlm.nih.gov/pubmed/1846184
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