Herpes simplex virus transactivator ICP4 operationally substitutes for the cellular transcription factor Sp1 for efficient expression of the viral thymidine kinase gene.

The herpes simplex virus type 1 (HSV-1) ICP4 protein is a transcriptional activator of many eucaryotic RNA polymerase II promoters. The HSV-1 thymidine kinase gene (tk) promoter is induced by ICP4 and contains binding sites for the cellular transcription factors TFIID, Sp1, and CCAAT-binding protein...

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Detalles Bibliográficos
Publicado en:J Virol
Main Authors: Imbalzano, A N, Coen, D M, DeLuca, N A
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239793/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1846184/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.2.565-574.1991
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