Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status

BACKGROUND: Aberrant activation of the nuclear factor kappaB (NF-κB) pathway has been previously implicated as a crucial signal promoting tumorigenesis. However, how NF-κB acts as a key regulatory node to modulate global gene expression, and contributes to the malignant heterogeneity of head and nec...

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Bibliographic Details
Main Authors: Yan, Bin, Chen, Guang, Saigal, Kunal, Yang, Xinping, Jensen, Shane T, Van Waes, Carter, Stoeckert, Christian J, Chen, Zhong
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397505/
https://ncbi.nlm.nih.gov/pubmed/18334025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2008-9-3-r53
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