X-ray Structure of 4,4′-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14α-Demethylase (CYP51)

A universal step in the biosynthesis of membrane sterols and steroid hormones is the oxidative removal of the 14α-methyl group from sterol precursors by sterol 14α-demethylase (CYP51). This enzyme is a primary target in treatment of fungal infections in organisms ranging from humans to plants, and d...

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Bibliografske podrobnosti
Main Authors: Eddine, Ali Nasser, von Kries, Jens P., Podust, Mikhail V., Warrier, Thulasi, Kaufmann, Stefan H. E., Podust, Larissa M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2008
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397474/
https://ncbi.nlm.nih.gov/pubmed/18367444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801145200
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