MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression

Homeobox (HOX) genes play a definitive role in determination of cell fate during embryogenesis and hematopoiesis. MLL-related leukemia is coincident with increased expression of a subset of HOX genes, including HOXA9. MLL functions to maintain, rather than initiate, expression of its target genes. H...

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Autori principali: Erfurth, Frank E., Popovic, Relja, Grembecka, Jolanta, Cierpicki, Tomasz, Theisler, Catherine, Xia, Zhen-Biao, Stuart, Tara, Diaz, Manuel O., Bushweller, John H., Zeleznik-Le, Nancy J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396713/
https://ncbi.nlm.nih.gov/pubmed/18483194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800090105
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