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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
The premature-ageing disease Hutchinson-Gilford Progeria Syndrome (HGPS) is caused by constitutive production of progerin, a mutant form of the nuclear architectural protein lamin A1,2. Progerin is also expressed sporadically in wild-type cells and has been linked to physiological ageing3. Cells fro...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396576/ https://ncbi.nlm.nih.gov/pubmed/18311132 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1708 |
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