Estrogen and Aging Affect Synaptic Distribution of Phosphorylated LIM Kinase (LIMK) in CA1 Region of Female Rat Hippocampus

17β-Estradiol (E) increases axospinous synapse density in the hippocampal CA1 region of young female rats, but not in aged rats. This may be linked to age-related alterations in signaling pathways activated by synaptic estrogen receptor α (ER-α) that potentially regulate spine formation, such as LIM...

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Autors principals: Yildirim, Murat, Janssen, William G.M., Tabori, Nora E., Adams, Michelle M., Yuen, Genevieve S., Akama, Keith T., McEwen, Bruce S., Milner, Teresa A., Morrison, John H.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396523/
https://ncbi.nlm.nih.gov/pubmed/18294775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2008.01.004
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