Copper sensing function of Drosophila metal-responsive transcription factor-1 is mediated by a tetranuclear Cu(I) cluster

Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd. Here, we characterize a novel cysteine-rich domain which is crucial for sensing excess intracellular copper by dMTF-1. Transgenic flies expressing mutant dMTF...

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Main Authors: Chen, Xiaohua, Hua, Haiqing, Balamurugan, Kuppusamy, Kong, Xiangming, Zhang, Limei, George, Graham N., Georgiev, Oleg, Schaffner, Walter, Giedroc, David P.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2008
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396432/
https://ncbi.nlm.nih.gov/pubmed/18411209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn103
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