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A Probabilistic Model of Local Sequence Alignment That Simplifies Statistical Significance Estimation
Sequence database searches require accurate estimation of the statistical significance of scores. Optimal local sequence alignment scores follow Gumbel distributions, but determining an important parameter of the distribution (λ) requires time-consuming computational simulation. Moreover, optimal al...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2008
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396288/ https://ncbi.nlm.nih.gov/pubmed/18516236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000069 |
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