Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State

Herpes simplex virus mutants lacking the vhs protein are severely attenuated in animal models of pathogenesis and exhibit reduced growth in primary cell culture. As a result of these properties, viruses with vhs deleted have been proposed as live-attenuated vaccines. Despite these findings and their...

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Bibliografski detalji
Glavni autori: Pasieka, Tracy Jo, Lu, Betty, Crosby, Seth D., Wylie, Kristine M., Morrison, Lynda A., Alexander, Diane E., Menachery, Vineet D., Leib, David A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Virus-Cell Interactions
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395185/
https://ncbi.nlm.nih.gov/pubmed/18367525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02047-07
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