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Herpes Simplex Virus Virion Host Shutoff Attenuates Establishment of the Antiviral State

Herpes simplex virus mutants lacking the vhs protein are severely attenuated in animal models of pathogenesis and exhibit reduced growth in primary cell culture. As a result of these properties, viruses with vhs deleted have been proposed as live-attenuated vaccines. Despite these findings and their...

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Sonraí Bibleagrafaíochta
Main Authors: Pasieka, Tracy Jo, Lu, Betty, Crosby, Seth D., Wylie, Kristine M., Morrison, Lynda A., Alexander, Diane E., Menachery, Vineet D., Leib, David A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395185/
https://ncbi.nlm.nih.gov/pubmed/18367525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02047-07
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