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Evolutionary history and functional implications of protein domains and their combinations in eukaryotes

BACKGROUND: In higher multicellular eukaryotes, complex protein domain combinations contribute to various cellular functions such as regulation of intercellular or intracellular signaling and interactions. To elucidate the characteristics and evolutionary mechanisms that underlie such domain combina...

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Main Authors: Itoh, Masumi, Nacher, Jose C, Kuma, Kei-ichi, Goto, Susumu, Kanehisa, Minoru
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394772/
https://ncbi.nlm.nih.gov/pubmed/17588271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2007-8-6-r121
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