Plasma concentrations of 5-fluorouracil and F-β-alanine following oral administration of S-1, a dihydropyrimidine dehydrogenase inhibitory fluoropyrimidine, as compared with protracted venous infusion of 5-fluorouracil

The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(−2) da...

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Main Authors: Yamada, Y, Hamaguchi, T, Goto, M, Muro, K, Matsumura, Y, Shimada, Y, Shirao, K, Nagayama, S
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2003
Assuntos:
Clinical
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394492/
https://ncbi.nlm.nih.gov/pubmed/12942110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601224
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