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Inhibition of telomerase activity in malignant glioma cells correlates with their sensitivity to temozolomide
Temozolomide (TMZ, 3,4-dihydro-3-methyl-4-oxoimidazo [5,1-d]-as-tetrazine-8-carboxamide) is a new alkylating agent with promising antitumour efficacy for malignant gliomas. The resistance of tumour cells to TMZ is primarily associated with levels of the alkylguanine alkyltransferase (AGT). O(6)-benz...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2003
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394478/ https://ncbi.nlm.nih.gov/pubmed/12942127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601193 |
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