KCa3.1 channel inhibition sensitizes malignant gliomas to temozolomide treatment

Malignant gliomas are among the most frequent and aggressive cerebral tumors, characterized by high proliferative and invasive indexes. Standard therapy for patients, after surgery and radiotherapy, consists of temozolomide (TMZ), a methylating agent that blocks tumor cell proliferation. Currently,...

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Veröffentlicht in:Oncotarget
Hauptverfasser: D'Alessandro, Giuseppina, Grimaldi, Alfonso, Chece, Giuseppina, Porzia, Alessandra, Esposito, Vincenzo, Santoro, Antonio, Salvati, Maurizio, Mainiero, Fabrizio, Ragozzino, Davide, Angelantonio, Silvia Di, Wulff, Heike, Catalano, Myriam, Limatola, Cristina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5058717/
https://ncbi.nlm.nih.gov/pubmed/27096953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8761
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