Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome P450 3A4 substrate, in patients with chronic myeloid leukaemia

The inhibition by imatinib of the cytochrome P450 3A4 isoenzyme may reduce the CYP3A4-mediated metabolic clearance of clinically important coadministered drugs. The main purpose of this study was to evaluate the effect of the coadministration of imatinib on the pharmacokinetics of simvastatin, a pro...

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Hlavní autoři: O'Brien, S G, Meinhardt, P, Bond, E, Beck, J, Peng, B, Dutreix, C, Mehring, G, Milosavljev, S, Huber, C, Capdeville, R, Fischer, T
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2003
Témata:
Clinical
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394453/
https://ncbi.nlm.nih.gov/pubmed/14612892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601152
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