Further observations on LKB1/STK11 status and cancer risk in Peutz–Jeghers syndrome

Germline mutations in the LKB1/STK11 tumour suppressor gene cause Peutz–Jeghers syndrome (PJS), a rare dominant disorder. In addition to typical hamartomatous gastrointestinal polyps and pigmented perioral lesions, PJS is associated with an increased risk of tumours at multiple sites. Follow-up info...

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書誌詳細
主要な著者: Lim, W, Hearle, N, Shah, B, Murday, V, Hodgson, S V, Lucassen, A, Eccles, D, Talbot, I, Neale, K, Lim, A G, O'Donohue, J, Donaldson, A, Macdonald, R C, Young, I D, Robinson, M H, Lee, P W R, Stoodley, B J, Tomlinson, I, Alderson, D, Holbrook, A G, Vyas, S, Swarbrick, E T, Lewis, A A M, Phillips, R K S, Houlston, R S
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2003
主題:
Genetics and Genomics
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394252/
https://ncbi.nlm.nih.gov/pubmed/12865922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601030
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