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Roles of the PI-3K and MEK pathways in Ras-mediated chemoresistance in breast cancer cells
Activated Ras utilises several downstream pathways, including the mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway and the phosphoinositide 3-kinase (PI-3k)/Akt pathway, to promote cell proliferation and to inhibit apoptosis. To investigate which pathway plays a major role in Ras-in...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2394213/ https://ncbi.nlm.nih.gov/pubmed/12838322 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601048 |
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