BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells

Erythropoietin (Epo)-independent differentiation of erythroid progenitors is a major characteristic of myeloproliferative disorders, including chronic myeloid leukemia. Epo receptor (EpoR) signaling is crucial for normal erythroid development, as evidenced by the properties of Epo(−/−) and EpoR(−/−)...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Ghaffari, Saghi, Wu, Hong, Gerlach, Melissa, Han, Ying, Lodish, Harvey F., Daley, George Q.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1999
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23922/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557295/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13186
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