FoxO1 mediates insulin-dependent regulation of hepatic VLDL production in mice

Excessive production of triglyceride-rich VLDL is attributable to hypertriglyceridemia. VLDL production is facilitated by microsomal triglyceride transfer protein (MTP) in a rate-limiting step that is regulated by insulin. To characterize the underlying mechanism, we studied hepatic MTP regulation b...

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Autores principales: Kamagate, Adama, Qu, Shen, Perdomo, German, Su, Dongming, Kim, Dae Hyun, Slusher, Sandra, Meseck, Marcia, Dong, H. Henry
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2008
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391277/
https://ncbi.nlm.nih.gov/pubmed/18497885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32914
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