In vivo evaluation of a transdermal codrug of 6-β-naltrexol linked to hydroxybupropion in hairless guinea pigs

6-β-Naltrexol is the major active metabolite of naltrexone, NTX, a potent μ-opioid receptor antagonist used in the treatment of alcohol dependence and opioid abuse. Compared to naloxone, NTX has a longer duration of action largely attributed to 6-β-naltrexol. This study was carried out in order to d...

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Hlavní autoři: Kiptoo, Paul K., Paudel, Kalpana S., Hammell, Dana C., Hamad, Mohamed O., Crooks, Peter A., Stinchcomb, Audra L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390923/
https://ncbi.nlm.nih.gov/pubmed/18321686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2008.01.006
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