Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells

BACKGROUND/AIMS: The canonical Wnt signaling is frequently activated in human hepatocellular carcinoma (HCC). We previously demonstrated that up-regulation of Frizzled-7 receptor (FZD7) in HCC was associated with nuclear accumulation of wild-type β-catenin. Here, we investigated Wnt ligand(s) that m...

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Main Authors: Kim, Miran, Lee, Han Chu, Tsedensodnom, Orkhontuya, Hartley, Rochelle, Lim, Young-Suk, Yu, Eunsil, Merle, Philippe, Wands, Jack R
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390890/
https://ncbi.nlm.nih.gov/pubmed/18313787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2007.12.020
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