A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

Ribonuclease L (RNase L) is a latent endoribonuclease in an evolutionarily ancient interferon-regulated dsRNA-activated antiviral pathway. 2′–5′ oligoadenylate (2–5A), the product of dsRNA-activated oligoadenylate synthetases (OASes), binds to ankyrin repeats near the amino terminus of RNase L, init...

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Main Authors: Townsend, Hannah L., Jha, Babal K., Han, Jian-Qiu, Maluf, N. Karl, Silverman, Robert H., Barton, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390801/
https://ncbi.nlm.nih.gov/pubmed/18426919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.958908
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