Adenosine 3′,5′-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors

Nucleoside analog reverse transcriptase inhibitors (NRTI) are known to directly inhibit mitochondrial complex I activity as well as various mitochondrial kinases. Recent observations that complex I activity and superoxide production are modulated through cAMP-dependent phosphorylation suggests a mec...

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Bibliographic Details
Main Authors: Lund, Kaleb C., Wallace, Kendall B.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390784/
https://ncbi.nlm.nih.gov/pubmed/17904600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.08.015
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