Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum.

The anaerobic bacterium Eubacterium lentum, a common constituent of the intestinal microflora, inactivates digoxin by reducing the unsaturated lactone ring. Reduction of the cardiac glycoside by growing cultures of E. lentum ATCC 25559 proceeded in a stereospecific manner, with the 20R-dihydrodigoxi...

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Detalles Bibliográficos
Publicado en:Appl Environ Microbiol
Main Authors: Robertson, L W, Chandrasekaran, A, Reuning, R H, Hui, J, Rawal, B D
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 1986
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC239061/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3729400/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.51.6.1300-1303.1986
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