Reduction of digoxin to 20R-dihydrodigoxin by cultures of Eubacterium lentum.

The anaerobic bacterium Eubacterium lentum, a common constituent of the intestinal microflora, inactivates digoxin by reducing the unsaturated lactone ring. Reduction of the cardiac glycoside by growing cultures of E. lentum ATCC 25559 proceeded in a stereospecific manner, with the 20R-dihydrodigoxi...

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Autors principals: Robertson, L W, Chandrasekaran, A, Reuning, R H, Hui, J, Rawal, B D
Format: Artigo
Idioma:Inglês
Publicat: 1986
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC239061/
https://ncbi.nlm.nih.gov/pubmed/3729400
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