Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone

BACKGROUND: Legionella pneumophila pneumonia often exacerbates acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Apoptosis of alveolar epithelial cells is considered to play an important role in the pathogenesis of ALI and ARDS. In this study, we investigated the precise mechan...

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Détails bibliographiques
Auteurs principaux: Furugen, Makoto, Higa, Futoshi, Hibiya, Kenji, Teruya, Hiromitsu, Akamine, Morikazu, Haranaga, Shusaku, Yara, Satomi, Koide, Michio, Tateyama, Masao, Mori, Naoki, Fujita, Jiro
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2008
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2390540/
https://ncbi.nlm.nih.gov/pubmed/18447956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-9-39
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