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Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus

We report the crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus, a major human pathogen, to 2.8-Å resolution. This enzyme is a key target for developing specific antiviral therapy. The structure of the catalytic domain contains 531 residues folded in the characteristic finge...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Bressanelli, Stéphane, Tomei, Licia, Roussel, Alain, Incitti, Ilario, Vitale, Rosa Letizia, Mathieu, Magali, De Francesco, Raffaele, Rey, Félix A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23895/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557268/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13034
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