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3,3′-Diindolylmethane reduces levels of HIF-1α and HIF-1 activity in hypoxic cultured human cancer cells

3,3′-Diindolylmethane (DIM) is a chemopreventive and chemotherapeutic phytochemical derived from the metabolism of indoles found at high concentrations in cruciferous vegetables. We have previously shown that DIM exhibits anti-angiogenic properties in cultured vascular endothelial cells and in Matri...

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Autori principali: Riby, Jacques E., Firestone, Gary L., Bjeldanes, Leonard F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2387239/
https://ncbi.nlm.nih.gov/pubmed/18329003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.01.017
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