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Mutagenesis Studies of Substrate Recognition and Catalysis in the Sortase A Transpeptidase from Staphylococcus aureus

The Staphylococcus aureus transpeptidase sortase A (SrtA) is responsible for anchoring a range of virulence- and colonization-associated proteins to the cell wall. SrtA recognizes substrates that contain a C-terminal LPXTG motif. This sequence is cleaved following the threonine, and an amide bond is...

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Autors principals: Bentley, Matthew L., Lamb, Erin C., McCafferty, Dewey G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386945/
https://ncbi.nlm.nih.gov/pubmed/18375951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800974200
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