Pellino 3b Negatively Regulates Interleukin-1-induced TAK1-dependent NFκB Activation

IL-1 receptor-associated kinase (IRAK) is phosphorylated, ubiquitinated, and degraded upon interleukin-1 (IL-1) stimulation. In this study, we showed that IRAK can be ubiquitinated through both Lys-48- and Lys-63-linked polyubiquitin chains upon IL-1 induction. Pellino 3b is the RING-like motif ubiq...

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Bibliographic Details
Main Authors: Xiao, Hui, Qian, Wen, Staschke, Kirk, Qian, Youcun, Cui, Grace, Deng, Li, Ehsani, Mariam, Wang, Xiliang, Qian, Yue-Wei, Chen, Zhijian J., Gilmour, Raymond, Jiang, Zhengfan, Li, Xiaoxia
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386918/
https://ncbi.nlm.nih.gov/pubmed/18326498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M706931200
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