TAB4 Stimulates TAK1-TAB1 Phosphorylation and Binds Polyubiquitin to Direct Signaling to NF-κB

Responses to transforming growth factor β and multiple cytokines involve activation of transforming growth factor β-activated kinase-1 (TAK1) kinase, which activates kinases IκB kinase (IKK) and MKK3/6, leading to the parallel activation of NF-κB and p38 MAPK. Activation of TAK1 by autophosphorylati...

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Detalhes bibliográficos
Main Authors: Prickett, Todd D., Ninomiya-Tsuji, Jun, Broglie, Peter, Muratore-Schroeder, Tara L., Shabanowitz, Jeffrey, Hunt, Donald F., Brautigan, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443674/
https://ncbi.nlm.nih.gov/pubmed/18456659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800943200
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