Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells

Hyaluronan is a major component of the pericellular matrix surrounding tumor cells, including colon carcinomas. Elevated cycooxygenase-2 levels have been implicated in several malignant properties of colon cancer. We now show for the first time a strong link between hyaluronan-CD44 interaction and c...

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Autors principals: Misra, Suniti, Obeid, Lina M., Hannun, Yusuf A., Minamisawa, Susumu, Berger, Franklin G., Markwald, Roger R., Toole, Bryan P., Ghatak, Shibnath
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2008
Matèries:
Mechanisms of Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386915/
https://ncbi.nlm.nih.gov/pubmed/18326857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M703811200
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