Delivery of CD44 shRNA/Nanoparticles within Cancer Cells: PERTURBATION OF HYALURONAN/CD44v6 INTERACTIONS AND REDUCTION IN ADENOMA GROWTH IN Apc Min/+ MICE

Our studies have shown that constitutive interactions between hyaluronan and CD44 on tumor cells induces various anti-apoptotic cell survival pathways through the formation of a multimeric signaling complex that contains activated receptor tyrosine kinases. Inhibition of the hyaluronan-CD44 interact...

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Detalhes bibliográficos
Main Authors: Misra, Suniti, Hascall, Vincent C., De Giovanni, Carla, Markwald, Roger R., Ghatak, Shibnath
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2673310/
https://ncbi.nlm.nih.gov/pubmed/19246453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806772200
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