Novel Dual Cyclooxygenase and Lipoxygenase Inhibitors Targeting Hyaluronan-CD44v6 Pathway and Inducing Cytotoxicity in Colon Cancer Cells

Cyclooxygenase-2 (COX-2) and 5-Lipoxygenase (5-LOX) enzyme have been found to play a role in promoting growth in colon cancer cell lines. The di-tert-butyl phenol class of compounds has been found to inhibit both COX-2 and 5-LOX enzymes with proven effectiveness in arresting tumor growth. In the pre...

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Bibliografiset tiedot
Päätekijät: Misra, Suniti, Ghatak, Shibnath, Patil, Neha, Dandawate, Prasad, Ambike, Vinita, Adsule, Shreelekha, Unni, Deepak, Swamy, K. Venkateswara, Padhye, Subhash
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895464/
https://ncbi.nlm.nih.gov/pubmed/23517721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.02.033
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