Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus

PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4, however, paradoxically results in fatal patent DA (PDA) in mice. Here we demonstrate that EP4-mediated signals promote DA closure by hyaluron...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Yokoyama, Utako, Minamisawa, Susumu, Quan, Hong, Ghatak, Shibnath, Akaike, Toru, Segi-Nishida, Eri, Iwasaki, Shiho, Iwamoto, Mari, Misra, Suniti, Tamura, Kouichi, Hori, Hideaki, Yokota, Shumpei, Toole, Bryan P., Sugimoto, Yukihiko, Ishikawa, Yoshihiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626128/
https://ncbi.nlm.nih.gov/pubmed/17080198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28639
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados