Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus

PGE, a potent vasodilator, plays a primary role in maintaining the patency of the ductus arteriosus (DA). Genetic disruption of the PGE-specific receptor EP4, however, paradoxically results in fatal patent DA (PDA) in mice. Here we demonstrate that EP4-mediated signals promote DA closure by hyaluron...

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Bibliografiska uppgifter
Huvudupphovsmän: Yokoyama, Utako, Minamisawa, Susumu, Quan, Hong, Ghatak, Shibnath, Akaike, Toru, Segi-Nishida, Eri, Iwasaki, Shiho, Iwamoto, Mari, Misra, Suniti, Tamura, Kouichi, Hori, Hideaki, Yokota, Shumpei, Toole, Bryan P., Sugimoto, Yukihiko, Ishikawa, Yoshihiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2006
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1626128/
https://ncbi.nlm.nih.gov/pubmed/17080198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28639
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