Raf Activation Is Regulated by Tyrosine 510 Phosphorylation in Drosophila

The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase (MAPK) signaling, and its aberrant activation has been implicated in multiple human cancers. However, the precise molecular mechanism of Raf activation, especially for B-Raf, remains unresolved. By genetic and biochemical stud...

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Bibliographic Details
Main Authors: Xia, Fan, Li, Jinghong, Hickey, Gavin W, Tsurumi, Amy, Larson, Kimberly, Guo, Dongdong, Yan, Shian-Jang, Silver-Morse, Louis, Li, Willis X
Format: Artigo
Language:Inglês
Published: Public Library of Science 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386837/
https://ncbi.nlm.nih.gov/pubmed/18494562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0060128
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