Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Levels of expression of the transcription factor Pax6 vary throughout corticogenesis in a rostro-lateral(high) to caudo-medial(low) gradient across the cortical proliferative zone. Previous loss-of-function studies have indicated that Pax6 is required for normal cortical progenitor proliferation, ne...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Manuel, Martine, Georgala, Petrina A., Carr, Catherine B., Chanas, Simon, Kleinjan, Dirk A., Martynoga, Ben, Mason, John O., Molinek, Michael, Pinson, Jeni, Pratt, Thomas, Quinn, Jane C., Simpson, T. Ian, Tyas, David A., van Heyningen, Veronica, West, John D., Price, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386558/
https://ncbi.nlm.nih.gov/pubmed/17202185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.02764
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge