Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Levels of expression of the transcription factor Pax6 vary throughout corticogenesis in a rostro-lateral(high) to caudo-medial(low) gradient across the cortical proliferative zone. Previous loss-of-function studies have indicated that Pax6 is required for normal cortical progenitor proliferation, ne...

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Detalhes bibliográficos
Main Authors: Manuel, Martine, Georgala, Petrina A., Carr, Catherine B., Chanas, Simon, Kleinjan, Dirk A., Martynoga, Ben, Mason, John O., Molinek, Michael, Pinson, Jeni, Pratt, Thomas, Quinn, Jane C., Simpson, T. Ian, Tyas, David A., van Heyningen, Veronica, West, John D., Price, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386558/
https://ncbi.nlm.nih.gov/pubmed/17202185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.02764
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