Retinoic Acid Stimulation of the Sodium/Iodide Symporter in MCF-7 Breast Cancer Cells Is Meditated by the Insulin Growth Factor-I/Phosphatidylinositol 3-Kinase and p38 Mitogen-Activated Protein Kinase Signaling Pathways

Context: All-trans retinoic acid (tRA) induces differentiation in MCF-7 breast cancer cells, stimulates sodium/iodide symporter (NIS) gene expression, and inhibits cell proliferation. Radioiodine administration after systemic tRA treatment has been proposed as an approach to image and treat some dif...

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Autores principales: Kogai, Takahiko, Ohashi, Emi, Jacobs, Megan S., Sajid-Crockett, Saima, Fisher, Myrna L., Kanamoto, Yoko, Brent, Gregory A.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Endocrine Society 2008
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386284/
https://ncbi.nlm.nih.gov/pubmed/18319322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2007-1627
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