Effects of disulfiram and dopamine beta-hydroxylase knockout on cocaine-induced seizures

The antialcoholism drug disulfiram has shown recent promise as a pharmacotherapy for treating cocaine dependence, probably via inhibition of dopamine β-hydroxylase (DBH), the enzyme that catalyzes the conversion of dopamine (DA) to norepinephrine (NE). We previously showed that DBH knockout (Dbh -/-...

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Bibliografiske detaljer
Main Authors: Gaval-Cruz, Meriem, Schroeder, Jason P., Liles, L. Cameron, Javors, Martin A., Weinshenker, David
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386143/
https://ncbi.nlm.nih.gov/pubmed/18329701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pbb.2008.02.009
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