Naturally occurring Bruton's tyrosine kinase mutations have no dominant negative effect in an X-linked agammaglobulinaemia cellular model

X-linked agammaglobulinaemia (XLA) is characterized by absence of mature B cells because of mutations in the Bruton's tyrosine kinase (Btk) gene. Btk-deficient early B cell precursors experience a block in their differentiation potentially reversible by the addition of an intact Btk gene. Btk e...

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Main Authors: Pérez de Diego, R, López-Granados, E, Rivera, J, Ferreira, A, Fontán, G, Bravo, J, García Rodríguez, MC, Bolland, S
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2008
Assuntos:
Translational Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2384054/
https://ncbi.nlm.nih.gov/pubmed/18241233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03589.x
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