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Bruton's tyrosine kinase expression and activity in X-linked agammaglobulinaemia (XLA): the use of protein analysis as a diagnostic indicator of XLA

Mutations in the Bruton's tyrosine kinase (BTK) gene result in XLA. Despite the large numbers of BTK mutations reported, no correlation can be made between the clinical phenotype and the gene defects. Analysis of Btk protein expression and activity in individuals with XLA was performed to chara...

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Autores principales: Gaspar, H B, Lester, T, Levinsky, R J, Kinnon, C
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Science Inc 1998
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1904924/
https://ncbi.nlm.nih.gov/pubmed/9486400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1998.00503.x
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