Human Rhinovirus 1B Exposure Induces Phosphatidylinositol 3-Kinase–dependent Airway Inflammation in Mice

Rationale: Infection with rhinovirus (RV) triggers exacerbations of asthma and chronic obstructive lung disease. Objectives: We sought to develop a mouse model of RV employing RV1B, a minor group serotype that binds to the low-density lipoprotein receptor. Methods: C57BL/6 mice were inoculated intra...

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Detalhes bibliográficos
Main Authors: Newcomb, Dawn C., Sajjan, Umadevi S., Nagarkar, Deepti R., Wang, Qiong, Nanua, Suparna, Zhou, Ying, McHenry, Christina L., Hennrick, Kenneth T., Tsai, Wan C., Bentley, J. Kelley, Lukacs, Nicholas W., Johnston, Sebastian L., Hershenson, Marc B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2008
Assuntos:
D. Pulmonary Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383993/
https://ncbi.nlm.nih.gov/pubmed/18276942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200708-1243OC
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