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Cis- and trans-splicing of mRNAs mediated by tRNA sequences in eukaryotic cells

The formation of chimeric mRNAs is a strategy used by human cells to increase the complexity of their proteome, as revealed by the ENCODE project. Here, we use Saccharomyces cerevisiae to show a way by which trans-spliced mRNAs can be generated. We demonstrate that a pretRNA inserted into a premRNA...

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Main Authors: Di Segni, Gianfranco, Gastaldi, Serena, Tocchini-Valentini, Glauco P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2383978/
https://ncbi.nlm.nih.gov/pubmed/18458335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800420105
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