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Transcriptional abnormality in myotonic dystrophy affects DMPK but not neighboring genes

Myotonic dystrophy (DM) is caused by the expansion of a trinucleotide repeat, CTG, in the 3′ untranslated region of a protein kinase gene, DMPK. We set out to determine what effect this expanded repeat has on RNA processing. The subcellular fractionation of RNA and the separate analysis of DMPK tran...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hamshere, Marion G., Newman, Emma E., Alwazzan, Madawi, Athwal, Balwinder S., Brook, J. David
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23832/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207102/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7394
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