Interleukin-2 downregulates hepatitis B virus gene expression in transgenic mice by a posttranscriptional mechanism.

We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) and interleukin-2 (IL-2) downregulate the hepatic steady-state content of hepatitis B virus (HBV) mRNA in vivo in HBV-transgenic mice and that the IL-2 effect is mediated by TNF-alpha. In the current study, we demonstrate tha...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Guilhot, S, Guidotti, L G, Chisari, F V
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238210/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8230465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.12.7444-7449.1993
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