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Viral determinants of simian immunodeficiency virus (SIV) virulence in rhesus macaques assessed by using attenuated and pathogenic molecular clones of SIVmac.

To identify viral determinants of simian immunodeficiency virus (SIV) virulence, two pairs of reciprocal recombinants constructed from a pathogenic (SIVmac239) and a nonpathogenic (SIVmac1A11) molecular clone of SIV were tested in rhesus macaques. A large 6.2-kb fragment containing gag, pol, env, an...

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Udgivet i:J Virol
Principais autores: Marthas, M L, Ramos, R A, Lohman, B L, Van Rompay, K K, Unger, R E, Miller, C J, Banapour, B, Pedersen, N C, Luciw, P A
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1993
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC238025/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8371353/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.10.6047-6055.1993
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